Tuesday, April 15, 2008

Fwd: Lung function predicts survival in a cohort of asbestos cement workers.



---------- Forwarded message ----------
From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Tue, Apr 15, 2008 at 5:53 PM
Subject: Lung function predicts survival in a cohort of asbestos cement workers.
To: mesothelioma77@gmail.com


[1]Int Arch Occup Environ Health. 2008 Apr 12;
Moshammer H, Neuberger M

PURPOSE: To study the predictive power of respiratory screening examinations a cohort of asbestos workers was followed from active work in an asbestos cement plant until death. METHODS: From a cohort with data on individual exposure since first employment 309 workers who had a preventive medical examination in 1989/1990 were observed until death or the end of 2006. The impact of asbestos exposure (fibre years) and of smoking history on lung function was examined by linear regression, on specific causes of death and total mortality by Cox regression. The prognostic value of lung function, chest X-ray, and various clinical findings regarding total mortality was also examined by Cox regression. RESULTS: Lung function proved to be the best predictor of survival apart from current smoking. Depending on the lung function variable an impairment by the interquartile range resulted in a hazard ratio of 1.5-1.6 while for current smokers it was 2.3. An increase of 70 fibre years (interquartile range) led to a hazard ratio of only 1.1. Lung function was influenced by asbestos exposure, current (but not former) smoking, and by pathological X-ray findings. The risk for pleural mesothelioma was dominated by time since first exposure to crocydolite in the pipe factory while the risk for bronchial cancer increased with smoking and total fibre years. An unexpected finding was an increase of gastric cancer in asbestos cement workers. CONCLUSION: Lung function decrease predicts risk of premature death better than exposure history and regular spirometry should therefore be offered as primary screening to all former asbestos workers. In workers with a history of high cumulative exposure or rapid lung function decrease or radiological signs (diffuse pleural thickening or small irregular opacities) more sensitive techniques (high resolution computer tomography) need to be applied. All smokers with a history of asbestos exposure should be given free smoking cessation therapy to prevent premature death and lung cancer in particular.



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Fw: Malignant pleural mesothelioma: utility of 18 F-FDG PET.



----- Forwarded Message ----
From: HubMed - mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Sunday, March 16, 2008 1:31:38 AM
Subject: Malignant pleural mesothelioma: utility of 18 F-FDG PET.

[1]Ann Ital Chir. 2007 Sep-Oct; 78(5): 393-6
Spitilli MG, Treglia G, Calcagni ML, Giordano A

Malignant Pleural Mesothelioma is a rare tumour that arise from the mesothelial cells of the pleura and in recent time the incidence of this disease is rising. Because of the implications for management and therapy, it is important to assess the accurate staging. 18F-fluorodeoxiglucose Positron Emission Tomography (18F-FDG PET) is become a useful tool in the diagnosis of many neoplasms, such as Malignant Pleural Mesothelioma. In particular it has been shown to be useful in the evaluation of the extent of pleural disease, in the establishment of lymph node involvement, in the evaluation of tumour invasion into the lung and thoracic wall, in the diagnosis of extrathoracic metastases, in the assessment of the response to treatment, and in planning radiotherapy. Developments in system technology, like improvements in hybrid system (integrated Positron Emission Tomography/Computed Tomography) and the discovery of new radiopharmaceuticals, promise to make PET much more useful and versatile in the future.



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Fw: Malignant Mesothelioma Resistance to Apoptosis: Recent Discoveries and their Implication for Effective Therapeutic Strategies.



----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Friday, March 14, 2008 7:43:07 PM
Subject: Malignant Mesothelioma Resistance to Apoptosis: Recent Discoveries and their Implication for Effective Therapeutic Strategies.

[1]Curr Med Chem. 2008; 15(7): 631-41
Villanova F, Procopio A, Rippo MR

Malignant Mesothelioma is an aggressive and fatal type of tumor. The incidence of mesothelioma has increased in the past 30 years and is now common as male cancers of the liver, bone and bladder, especially in Europe and Australia. The main risk factor is asbestos exposure even if other co-factor, such as simian virus 40 (SV40) could be implied in its etiology. Unfortunately, its incidence is expected to continue to increase for the next decades, also in rapidly industrializing countries, such as India, where it is not recognised as an occupational disease. Furthermore, some disastrous events, such as the World Trade Center Disaster, may contribute to increase future risk for mesothelioma. The treatment-resistant phenotype of mesothelioma is largely due to its ability to escape from the highly regulated apoptotic machinery. The understanding of the molecular mechanisms responsible of the malignant mesothelioma resistance to apoptosis is now advancing, allowing developing new therapeutic strategies to change the natural history and improve survival of patients. This review gives an overview of the main anti-apoptotic strategies devised by malignant mesothelioma and the therapeutic implication and opportunities for this cancer.



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Source: http://www.hubmed.org/display.cgi?uids=18336278
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Fwd: Karmanos Cancer Institute Research Supports Role of Inflammation to...



---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Apr 14, 2008 at 6:10 PM
Subject: Karmanos Cancer Institute Research Supports Role of Inflammation to...
To: mesothelioma77@gmail.com


Researchers at the Barbara Ann Karmanos Cancer Institute in Detroit today presented findings that support the role of inflammation in determining lung cancer risk, particularly among African-American women.

Mon, 14 Apr 2008 21:25:03 GMT


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Fwd: Mouth test could predict lung cancer, study finds (Reuters via Yahoo! News)



---------- Forwarded message ----------
From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Sun, Apr 13, 2008 at 6:32 PM
Subject: Mouth test could predict lung cancer, study finds (Reuters via Yahoo! News)
To: mesothelioma77@gmail.com


Damage to cells lining the mouth can predict similar damage in the lungs that eventually leads to lung cancer in smokers, U.S. researchers reported on Sunday.

Sun, 13 Apr 2008 21:44:59 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=124simpnf/*http%3A//news.yahoo.com/s/nm/20080413/hl_nm/cancer_lung_mouth_dc_1
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Fwd: Mouth test could predict lung cancer (The Times of India)



---------- Forwarded message ----------
From: Yahoo! News Search Results for lung cancer <rssfwd@rssfwd.com>
Date: Mon, Apr 14, 2008 at 6:10 PM
Subject: Mouth test could predict lung cancer (The Times of India)
To: mesothelioma77@gmail.com


WASHINGTON: Damage to cells lining the mouth can predict similar damage in the lungs that eventually leads to lung cancer in smokers, US researchers reported.

Mon, 14 Apr 2008 18:49:47 GMT

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Source: http://us.rd.yahoo.com/dailynews/rss/search/lung+cancer/SIG=1336jjlc2/*http%3A//timesofindia.indiatimes.com/Mouth_test_could_predict_lung_cancer/articleshow/2951397.cms
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